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Long-term kidney graft survival is affected by different variables including donor condition, ischemia-reperfusion injury, and graft rejection during the transplantation process. The complement system is an important mediator of renal ischemia-reperfusion injury and in rejecting allografts. However, donor complement C3 seems to be crucial in renal transplantation-related injury as renal injury is attenuated in C3 deficient kidney grafts. Interestingly, before ischemia-reperfusion induced C3 expression, C3 is already induced in donors suffering from brain death. Therefore, strategies targeting complement activation in the brain-dead donor may increase graft viability and transplant outcome.

Original publication

DOI

10.1097/TP.0b013e3181683cf5

Type

Journal article

Journal

Transplantation

Publication Date

15/04/2008

Volume

85

Pages

923 - 927

Keywords

Brain Death, Complement System Proteins, Humans, Kidney Transplantation, Tissue Donors