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Infection of surgical meshes used in abdominal wall reconstructions often leads to removal of the implant and increases patient morbidity due to repetitive operations and hospital administrations. Treatment with antibiotics is ineffective due to the biofilm mode of growth of the infecting bacteria and bears the risk of inducing antibiotic resistance. Hence there is a need for alternative methods to prevent and treat mesh infection. Nitric oxide (NO)-releasing coatings have been demonstrated to possess bactericidal properties in vitro. It is the aim of this study to assess possible benefits of a low concentration NO-releasing carbon-based coating on monofilament polypropylene meshes with respect to infection control in vitro and in vivo. When applied on surgical meshes, NO-releasing coatings showed significant bactericidal effect on in vitro biofilms of Staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa and CNS. However, using bioluminescent in vivo imaging, no beneficial effects of this NO-releasing coating on subcutaneously implanted surgical meshes in mice could be observed.

Original publication

DOI

10.1016/j.actbio.2009.01.041

Type

Journal article

Journal

Acta Biomater

Publication Date

07/2009

Volume

5

Pages

1905 - 1910

Keywords

Animals, Anti-Bacterial Agents, Connective Tissue, Diffusion, Drug Implants, Female, Mice, Mice, Inbred BALB C, Nitric Oxide, Polyvinyls, Prostheses and Implants, Staphylococcal Infections