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The increased demand for organs has led to the increased usage of "higher risk" kidney and liver grafts. These grafts from donation after circulatory death or expanded criteria donors are more susceptible to preservation injury and have a higher risk of unfavorable outcomes. Dynamic, instead of static, preservation could allow for organ optimization, offering a platform for viability assessment, active organ repair and resuscitation. Ex situ machine perfusion and in situ regional perfusion in the donor are emerging as potential tools to preserve and resuscitate vulnerable grafts. Preclinical findings have ignited clinical organ preservation research that investigates dynamic preservation, its various modes (continuous, preimplantation) and temperatures (hypo-, sub, or normothermic). This review outlines the current status of dynamic preservation of kidney and liver grafts and describes ongoing research and emerging clinical trials.

Original publication

DOI

10.1111/ajt.13778

Type

Journal article

Journal

Am J Transplant

Publication Date

09/2016

Volume

16

Pages

2545 - 2555

Keywords

clinical research/practice, clinical trial, kidney transplantation/nephrology, liver transplantation/hepatology, organ perfusion and preservation, organ procurement and allocation, Animals, Graft Survival, Humans, Kidney Transplantation, Liver Transplantation, Organ Preservation, Organ Preservation Solutions, Resuscitation, Tissue Donors