Surgical Intervention Trials Unit

situ@ndorms.ox.ac.uk

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Success for Dr Anjali Shah at the Vice Chancellor’s Awards

Dr Anjali Shah from SITU-NDORMS at the Botnar Institute wins the Research Culture Award

Justin Wormald wins NIHR awards and takes up position as SITU Deputy Director

NDORMS alumnus Justin Wormald has been awarded an NIHR Academic Clinical Lectureship and an NIHR Development and Skills Enhancement (DSE) Award, as well as being appointed as Deputy Director of the Surgical Trials Intervention Unit (SITU-NDORMS).

BOASTiC 2024

The Bristol, Oxford and Aberdeen Surgical Trials Units are running a 3-day surgical research training event on surgical trials for foundation, core and specialist trainees of all surgical specialities. Students work collaboratively to learn how to design and conduct RCTs in surgery that answer research questions of relevance to surgeons, patients and the NHS.

Professor David Beard named NIHR Senior Investigator

NDORMS Professor of Musculoskeletal and Surgical Science, David Beard, has been named National Institute of Health Research (NIHR) Senior Investigator.

New approach to nail bed injury surgery could significantly cut NHS costs

According to a new Oxford study, changing clinical practice for finger injuries in children could save the NHS £720,000 per year.

Going straight to surgery found to be better than undergoing rehabilitation first for longstanding anterior cruciate ligament injury

New research, funded by the National Institute for Health and Care Research (NIHR), shows initial surgery to be more successful and cost effective than undergoing treatment with rehabilitation first to treat longstanding anterior cruciate ligament injury.

WELCOME TO THE SURGICAL INTERVENTION TRIALS UNIT (SITU NDORMS)

SITU is one of eight Royal College of Surgeons of England specialist trials centres dedicated to evaluating surgical intervention, mainly by generating randomised control trial evidence. We are a multidisciplinary team who provide, guidance, training and support for the development of new surgical trials and future trialists. We draw upon the considerable methodological and practical trials expertise in Oxford including statistical, ethical, health economic, systematic review, clinical network resources and the IDEAL collaboration.

Currently, less than 5% of government funding for medical research goes into surgery

ABOUT

We are a centre of excellence in surgical trials, answering important global surgical questions.

About us

RESEARCH

Read about our research and collaborations in the medical and healthcare research community.

Our research

TEAM

SITU at Oxford Open Doors 2017

Meet our multidisciplinary team of worldwide experts in surgical trials.

Our team

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Selected publications

Cost-effectiveness analysis of a pragmatic randomized trial evaluating surgical reconstruction versus rehabilitation in patients with long-standing anterior cruciate ligament injury.

Leal J. et al, (2024), Bone joint j, 106-B, 38 - 45

Effectiveness of nail bed repair in children with or without replacing the fingernail: NINJA multicentre randomized clinical trial.

Jain A. et al, (2023), Br j surg, 110, 432 - 438

Remote symptom monitoring with Ecological Momentary Computerized Adaptive Testing (EMCAT): a platform for frequent, low-burden and personalized patient-reported outcome measures (Preprint)

Harrison C. et al, (2023)

Item response theory may account for unequal item weighting and individual-level measurement error in trials that use PROMs: a psychometric sensitivity analysis of the TOPKAT trial.

Harrison CJ. et al, (2023), J clin epidemiol, 158, 62 - 69

Rehabilitation versus surgical reconstruction for non-acute anterior cruciate ligament injury (ACL SNNAP): a pragmatic randomised controlled trial.

Beard DJ. et al, (2022), Lancet, 400, 605 - 615

Efficacy of Liposomal Bupivacaine and Bupivacaine Hydrochloride vs Bupivacaine Hydrochloride Alone as a Periarticular Anesthetic for Patients Undergoing Knee Replacement: A Randomized Clinical Trial

HAMILTON T. et al, (2022), Jama surgery

Placebo comparator group selection and use in surgical trials: the ASPIRE project including expert workshop.

Beard DJ. et al, (2021), Health technol assess, 25, 1 - 52

Comparison of the clinical and cost effectiveness of two management strategies (rehabilitation versus surgical reconstruction) for non-acute anterior cruciate ligament (ACL) injury: study protocol for the ACL SNNAP randomised controlled trial.

Davies L. et al, (2020), Trials, 21

Considerations and Methods for Placebo Controls in Surgical Trials: State of the Art Review and ASPIRE Guidance

BEARD DJ. et al, (2019), The lancet

Study of Peri-Articular Anaesthetic for Replacement of the Knee (SPAARK): study protocol for a patient-blinded, randomised controlled superiority trial of liposomal bupivacaine.

Knight R. et al, (2019), Trials, 20

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