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Jonathan Cook

BSc, PhD

Associate Professor, Deputy Director of SITU



My main research interest is in the design, conduct, analysis and reporting of randomised controlled trials (particularly surgical trials). Key areas of interest include specification of the target difference in the sample size calculation, addressing interventional expertise, and methods for improving recruitment.


I also have extensive experience in systematic reviews of randomised controlled trials and diagnostic research. I have collaborated on numerous projects including randomised trials, observational and diagnostic studies, methodological projects and systematic reviews in a variety of clinical areas (anaethesia, cardiovascular, ear nose and throat, general surgery, obstetrics and gynaecology, ophthalmology, orthopaedics, plastic surgery, primary care, and urology amongst others).


I graduated from the University of Aberdeen with a BSc in Statistics. Following this I undertook a PhD on the statistical assessment of learning curve effects in randomised controlled trials. I worked at the Health Services Research Unit at the University of Aberdeen for a number of years in various roles. In 2010, I was awarded a MRC UK Methodology Fellowship focusing upon expertise-based trial designs and in August 2012 I became a Senior Research Fellow. I joined the Centre for Statistics in Medicine in 2013 initially on a secondment during which I was appointed to a University Lectureship (Associate Professorship) in NDORMS, University of Oxford.


My current projects include NINJA, MACRO, CSAW, eTHoS, DELTA, OPEN and TOPKAT trials. I hold a number of external responsibilities including serving on and chairing Data Monitoring and Steering committees for Clinical Trials, and also membership of grant funding panels (National Institute for Health Research’s Research for Patient Benefit and Health Technology Assessment programmes). Additionally, I hold an Associate Editor position for Clinical Trials, Editorial Board membership for BMC Trials journal, and I also serve as a statistical consultant for the British Journal of Surgery.

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Recent publications

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